Fig. 1

EW increases depressive-like behaviors and hyperactivity in marble-burying test during the juvenile period. (A) Schedule for Experiment 1. The mice were divided into NW and EW groups by weaning. EW mice (n = 21) were weaned on PD16 and NW mice (n = 44) were co-housed with dams until PD28. (B) The total duration of immobility during the tail suspension test in EW and NW mice. Distance moved (C) and number of marbles buried (D) in the marble burying test. The NW is black, and the EW is red. Data were represented as mean ± s.e.m. Comparison of performance in behavioral experiments at 4 and 8 wk of age; ##p < 0.01, ###p < 0.001. Comparison between EW and NW mice; * p < 0.05, ***  p< 0.001