Table 3 Connections of microbial taxa directly interacting with DMI, RFI and ADG phenotypes

DMI

 -C.aminophilum sp.

60

6

5

48

Steroid biosynthesis

Proteasomal processes

 -Butyrivibrio

69

24

4

40

Nucleic acid binding

 -S.copri sp.

57

12

4

40

Cholesterol biosynthesis

 -R.faecis sp.

186

83

9

93

Cholesterol homeostasis

 -Lachnobacterium

53

6

2

44

Transcription

 -Prevotella

73

6

66

Carbohydrate metabolism

 -Roseburia

187

86

9

91

Steroid biosynthesis

Metabolic pathways

 -L.ruminis sp.

65

19

4

41

Retinoid binding

 -L.salivarius sp.

160

74

4

81

Steroid biosynthesis

Metabolic pathways

 -Succinivibrio

42

20

1

20

Plasma membrane

RFI

 -Methanobrevibacter

426

78

2

346

Metabolic pathways

MAPK signaling

Lipid transporter activity

Catabolic processes

 -Pirellulales

331

72

5

253

Ras signaling pathway

Interferon signaling

Steroid catabolic process

Inflammatory response

 -Planctomycetes

323

72

5

245

Interferon signaling

 -Planctomycetia

331

72

5

253

Ras signaling pathway

Interferon signaling

Steroid catabolic process

Inflammatory response

 -Pyramidobacter

89

21

67

B-cell receptor signaling

Chemokine signaling

T-cell receptor signaling

Immunodeficiency

 -Succiniclasticum

43

16

25

Plasma membrane

 -Synergistales

185

33

151

Hippo signaling

Immunodeficiency

 -Synergistetes

185

33

151

Hippo signaling

Immunodeficiency

 -Synergistia

185

33

151

Hippo signaling

Immunodeficiency

ADG

 -CW040

217

72

6

138

Steroid biosynthesis

Metabolic pathways

Citrate cycle

 -D.D168 sp.

26

5

20

Ras signaling pathway

 -Desulfovibrio

27

4

22

Endoplasmic reticulum

 -Succiniclasticum

43

16

25

Plasma membrane