Skip to main content

Table 4 Metabolites of interest at day 16 ± 0.6 (T1)

From: Intrauterine growth restriction, defined by an elevated brain-to-liver weight ratio, affects faecal microbiota composition and, to a lesser extent, plasma metabolome profile at different ages in pigs

Metabolite

VIP

Loading

Tyrosine

0.20

−0.04

Leucine

0.20

0.04

Aspartate

0.19

0.04

Sarcosine

0.19

0.17

Alanine

0.18

0.27

Myo-inositol

0.16

0.26

Serine

0.16

0.17

Citramalate

0.15

0.32

2-Oxoglutarate

0.15

0.18

Glycerol

0.15

0.25

Acetate

0.14

0.19

2-Aminobutyrate

0.14

0.25

Threonine

0.13

−0.24

Beta-alanine

0.13

−0.04

Arginine

0.13

−0.18

Phenylalanine

0.13

0.14

Lysine

0.13

0.14

Glucose

0.12

0.25

Glyoxylate

0.12

0.06

Glutamine

0.12

0.25

Isoleucine

0.11

0.19

3-Hydroxyisobutyrate

0.11

0.01

TMAO

0.11

−0.12

Citrate

0.10

0.10

Dimethyl-sulfone

0.09

0.18

Glycine

0.09

−0.02

Ascorbate

0.09

0.18

Mannose

0.08

0.16

Betaine

0.08

0.17

Asparagine

0.08

0.01

Succinate

0.08

−0.12

Formate

0.07

−0.13

Creatine

0.07

−0.09

Valine

0.07

0.14

3-Aminoisobutyrate

0.06

−0.08

Acetone

0.06

−0.11

Methionine

0.06

−0.04

N,N-dimethylglycine

0.05

0.01

Arabinose

0.04

0.05

Fumarate

0.03

−0.06

Trans-4-hydroxy-L-proline

0.02

0.02

Proline

0.02

−0.03

Lactate

0.02

−0.03

Choline

0.01

−0.02

  1. Identification of metabolites of interest at day 16 ± 0.6 (T1) of age through the combination of the variable importance in the projection (VIP) and the loading between the metabolite in the X matrix and the predictive latent variable (pLV) of the OPLS-DA model. Metabolites are sorted by decreasing VIP