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Table 5 Metabolites of interest at day 63 ± 8.6 (T2)

From: Intrauterine growth restriction, defined by an elevated brain-to-liver weight ratio, affects faecal microbiota composition and, to a lesser extent, plasma metabolome profile at different ages in pigs

Metabolite

VIP

Loading

Asparagine

0.19

−0.24

Mannose

0.19

0.28

3-Aminoisobutyrate

0.18

0.15

Beta-alanine

0.18

0.24

Sarcosine

0.17

−0.13

Proline

0.16

−0.15

Fumarate

0.15

0.24

Arabinose

0.15

0.29

Ascorbate

0.14

0.27

2-Aminobutyrate

0.14

0.12

Aspartate

0.13

0.22

Succinate

0.13

−0.14

Glycine

0.13

0.11

Myo-inositol

0.13

0.10

Dimethyl-sulfone

0.12

0.27

Isoleucine

0.12

−0.09

Acetate

0.12

0.23

Creatine

0.11

0.23

Acetone

0.11

0.17

Methionine

0.11

0.20

Glyoxylate

0.11

0.23

Citrate

0.11

−0.03

Arginine

0.10

0.16

Tyrosine

0.09

−0.15

Glucose

0.09

0.20

TMAO

0.09

−0.02

Serine

0.08

−0.18

Phenylalanine

0.08

−0.03

Alanine

0.08

−0.17

Trans-4-hydroxy-L-proline

0.08

0.09

Lactate

0.07

−0.09

Formate

0.07

−0.14

Glycerol

0.07

0.08

Lysine

0.07

0.14

2-Oxoglutarate

0.06

0.04

Citramalate

0.06

−0.04

Glutamine

0.06

−0.10

Threonine

0.06

−0.00

N,N-dimethylglycine

0.05

0.06

3-Hydroxyisobutyrate

0.04

0.09

Leucine

0.04

0.05

Choline

0.04

0.01

Betaine

0.03

−0.06

Valine

0.01

−0.02

  1. Identification of metabolites of interest at day 63 ± 8.6 (T2) of age through the combination of the variable importance in the projection (VIP) and the loading between the metabolite in the X matrix and the predictive latent variable (pLV) of the OPLS-DA model. Metabolites are sorted by decreasing VIP