Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig

Table 10 Effects of A. muciniphila supplementation on hematology and plasma immunoglobulin concentrations in weaned pigs upon DSS challenge¹

Items	Treatments²				SEM	P-value
Items	CON	CA	DCON	DA	SEM	AKK	DSS	Interaction
WBC, 10⁹/L	34.86	29.62	29.34	32.30	5.07	0.75	0.70	0.27
Neut, %	28.43^b	35.33^ab	31.78^b	60.00^a	8.45	0.01	0.04	0.10
Lymph, %	61.90	56.13	50.74	45.50	11.43	0.49	0.19	0.97
Mono, %	1.56	6.975	2.72	6.62	4.83	0.18	0.91	0.82
Eos, %	0.88	0.70	1.68	1.66	0.90	0.88	0.20	0.90
Baso, %	1.12^ab	0.87^b	1.08^ab	1.34^a	0.13	0.93	0.03	0.01
Neut, 10⁹/L	9.00	10.28	9.32	18.93	4.63	0.11	0.18	0.21
Lymph, 10⁹/L	21.44	16.58	18.36	13.72	3.82	0.09	0.28	0.97
Mono, 10⁹/L	0.53	2.19	0.78	1.91	1.27	0.15	0.99	0.78
Eos, 10⁹/L	0.30	0.19	0.51	0.53	0.28	0.81	0.18	0.75
Baso, 10⁹/L	0.39	0.28	0.57	0.34	0.12	0.51	0.20	0.06
RBC, 10⁹/L	6.67	5.76	6.53	6.07	0.44	0.04	0.77	0.48
HGB, g/L	99.40	89.00	96.40	91.00	6.94	0.12	0.92	0.61
HCT, %	35.04	30.95	33.30	30.14	2.68	0.07	0.50	0.80
MCV, fL	52.80	53.50	51.00	50.00	2.43	0.93	0.13	0.62
MCHC, g/L	284.40	287.50	290.40	307.50	9.20	0.14	0.07	0.30
MCH, pg	15.20	15.25	14.60	15.20	0.64	0.47	0.47	0.54
RDW-SD, fL	50.00	48.00	46.20	45.40	3.88	0.61	0.25	0.83
RDW-CV, %	26.40	24.75	25.40	25.20	2.31	0.57	0.86	0.65
PLT, 10⁹/L	595.60^a	451.30^ab	579.6^ab	388.30^b	67.35	< 0.01	0.42	0.63
PCT, %	0.54	0.43	0.50	0.36	0.05	< 0.01	0.18	0.74
MPV, fL	9.06	9.55	8.64	8.78	0.40	0.29	0.06	0.55
PDW, %	15.00	14.75	14.80	15.20	0.25	0.69	0.50	0.10
IMG, %	0.68	0.87	1.08	1.04	0.20	0.78	0.32	0.68
IgG, g/L	3.13	3.34	3.92	3.93	0.46	0.75	0.05	0.76
IgM, g/L	0.44^b	0.59^ab	0.73^ab	0.78^a	0.11	0.22	< 0.01	0.52

WBC white blood cell, RBC red blood cell, HGB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCHC mean corpuscular hemoglobin concentration, RDW-SD red cell distribution width standard deviation, RDW-CV red Blood Cell Distribution Width Coefficient of Variation, PLT blood platelet count, PCT Plateletcrit, MPV mean platelet volume, PDW platelet volume distribution width, IMG immature Granulocytes, IgG immunoglobulin G, IgM immunoglobulin M
¹ Mean and total SEM are list in Separate columns, n = 6
² CON, pigs were fed with a basal diet; CA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959); DCON, pigs were fed with a basal diet and challenged by DSS; DA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959) and challenged by DSS
^{a, b} mean values within a row with unlike superscript letters were significantly different, P < 0.05

ISSN: 2524-4671