Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig

Table 4 Effects of A. muciniphila supplementation on serum biochemical parameters and immunoglobulin in weaned pigs upon DSS challenge¹

Items	Treatments²				SEM	P-value
Items	CON	CA	DCON	DA	SEM	AKK	DSS	Interaction
ALT, U/L	90.15	76.04	69.79	68.55	12.58	0.40	0.14	0.48
AST, U/L	46.79	40.78	31.91	55.33	12.02	0.32	0.99	0.10
ALP, U/L	205.40	225.80	179.60	128.00	45.07	0.73	0.05	0.34
UREA, mmol/L	2.07	2.77	2.44	2.93	0.89	0.36	0.68	0.87
CREA, µmol/L	66.01	69.81	69.33	65.86	5.82	0.97	0.94	0.39
CRP, mg/L	8.36^b	10.29^ab	11.32^ab	16.57^a	2.52	0.06	0.02	0.37

ALT glutamic pyruvic transaminase, AST glutamic oxaloacetic transaminase, ALP alkaline phosphatase, CREA creatinine, CRP C-reactive protein
¹ Mean and total SEM are list in Separate columns, n = 6
² CON, pigs were fed with a basal diet; CA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959); DCON, pigs were fed with a basal diet and challenged by DSS; DA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959) and challenged by DSS
^{a, b} mean values within a row with unlike superscript letters were significantly different, P < 0.05

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