Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig

Table 5 Effects of A. muciniphila supplementation on intestinal morphology in weaned pigs upon DSS challenge¹

Items	Treatments²				SEM	P-value
Items	CON	CA	DCON	DA	SEM	AKK	DSS	Interaction
Duodenum
Villus height, µm	400.50^a	379.70^a	339.3^b	266.79^c	18.06	< 0.01	< 0.01	0.05
Crypt depth, µm	177.40	172.70	189.90	173.70	9.33	0.13	0.32	0.39
VCR	2.26^a	2.21^a	1.79^b	1.55^c	0.05	< 0.01	< 0.01	0.01
Jejunum
Villus height, µm	350.80^a	356.50^a	298.30^b	258.90^b	15.31	0.14	< 0.01	0.05
Crypt depth, µm	161.20	150.90	166.30	147.60	6.92	< 0.01	0.85	0.40
VCR	2.18a	2.26a	1.79b	1.76b	0.05	0.552	< 0.01	0.10
Ileum
Villus height, µm	318.40^a	312.30^a	278.90^ab	218.60^c	16.38	0.01	< 0.01	0.03
Crypt depth, µm	143.10	144.20	155.20	130.70	9.42	0.10	0.92	0.07
VCR	2.23^a	2.18^a	1.81^b	1.70^c	0.04	< 0.01	< 0.01	0.36

VCR Villous height: crypt depth ratio
¹ Mean and total SEM are list in Separate columns, n = 6
² CON, pigs were fed with a basal diet; CA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959); DCON, pigs were fed with a basal diet and challenged by DSS; DA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959) and challenged by DSS
^{a, b} mean values within a row with unlike superscript letters were significantly different, P < 0.05

ISSN: 2524-4671