Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig

Table 7 Effects of A. muciniphila supplementation on intestinal mucosal enzyme activity in weaned pigs upon DSS challenge¹

Items	Treatments²				SEM	P-value
Items	CON	CA	DCON	DA	SEM	AKK	DSS	Interaction
Duodenum
IAP, U/g prot	44.95^a	40.82^a	33.11^b	20.50^c	3.51	< 0.01	< 0.01	0.04
Lactase, U/mg prot	145.50^a	142.80^a	111.20^b	78.09^c	10.48	0.02	< 0.01	0.04
Sucrase, U/mg prot	171.50^a	143.60^ab	129.70^ab	104.40^b	17.99	0.05	< 0.01	0.92
Maltase, U/mg prot	141.30^a	130.00^ab	106.50^bc	100.70^c	9.15	0.20	< 0.01	0.67
Jejunum
IAP, U/g prot	64.31^a	52.05^ab	39.55^bc	32.83^c	5.86	0.02	< 0.01	0.46
Lactase, U/mg prot	275.40^a	268.50^a	178.70^b	103.80^c	25.77	0.02	< 0.01	0.04
Sucrase, U/mg prot	256.90^a	187.50^ab	148.10^b	56.18^c	30.91	< 0.01	< 0.01	0.61
Maltase, U/mg prot	425.80^a	355.60^ab	309.40^bc	228.20^d	26.54	< 0.01	< 0.01	0.77
Ileum
IAP, U/g prot	47.96^a	48.05^a	46.05^ab	34.48^b	4.54	0.09	0.03	0.09
Lactase, U/mg prot	169.60	174.50	170.30	152.70	16.00	0.33	0.37	0.58
Sucrase, U/mg prot	150.10^a	126.40^ab	125.80^ab	86.36^b	19.92	0.04	0.04	0.58
Maltase, U/mg prot	139.30^a	129.90^ab	104.00^ab	93.07^b	14.48	0.34	< 0.01	0.94

IAP intestinal alkaline phosphatase
¹ Mean and total SEM are list in Separate columns, n = 6
^{2 a, b} mean values within a row with unlike superscript letters were significantly different, P < 0.05
³ CON, pigs were fed with a basal diet; CA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959); DCON, pigs were fed with a basal diet and challenged by DSS; DA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959) and challenged by DSS

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