Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig

Table 9 Effects of A. muciniphila supplementation on concentrations of SCFAs in the cecal and colonic digesta of weaned pigs upon DSS challenge¹

Items	Treatments²				SEM	P-value
Items	CON	CA	DCON	DA	SEM	AKK	DSS	Interaction
Cecum
Acetic acid	529.30^a	491.10^ab	324.10^b	352.00^ab	67.27	0.91	< 0.01	0.50
Propanoic acid	266.00^a	229.80^ab	147.80^ab	124.60^b	42.08	0.33	< 0.01	0.83
Isobutyric acid	4.92	8.89	5.29	8.59	2.74	0.08	0.99	0.86
Butyric acid	125.00^a	97.52^ab	62.72^ab	27.68^b	26.90	0.12	< 0.01	0.84
Isovaleric acid	1.94	9.04	1.93	8.64	4.78	0.06	0.95	0.95
Valeric acid	40.45	24.52	26.49	13.79	12.07	0.11	0.17	0.85
Colon
Acetic acid	475.50	428.40	330.90	388.00	74.50	0.93	0.10	0.34
Propanoic acid	220.80	194.30	145.90	151.60	41.97	0.73	0.06	0.59
Isobutyric acid	9.61	13.75	9.99	15.42	3.39	0.06	0.67	0.79
Butyric acid	123.60	103.50	78.32	69.69	31.50	0.53	0.09	0.80
Isovaleric acid	11.00	19.55	13.37	18.88	6.47	0.13	0.85	0.74
Valeric acid	42.12	28.04	31.98	24.85	14.83	0.33	0.53	0.74

¹ Mean and total SEM are list in Separate columns, n = 6
² CON, pigs were fed with a basal diet; CA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959); DCON, pigs were fed with a basal diet and challenged by DSS; DA, pigs were gavaged every day with 1 × 10¹¹ CFU/10 mL A. muciniphila (DSM 22959) and challenged by DSS
^{a, b} mean values within a row with unlike superscript letters were significantly different, P < 0.05

ISSN: 2524-4671